Recent publications by students

Bowers EV, Horvath JJ, Bond JE, Cianciolo GJ, Pizzo, SV. Encapsulation into ?2-Macroglobulin Enhances the Cell-Mediated Immune Response to Antigen. Manuscript in Progress.
Bowers EV, Horvath JJ, Bond JE, Cianciolo GJ, Pizzo, SV. Encapsulation into ?2-Macroglobulin Enhances the Cell-Mediated Immune Response to Antigen. 10th Annual Conference on Vaccine Research. Baltimore, MD, May 2007.

Schmidt C, Chi SL, Hoppner W, Das A, Pizzo, SV and Schachner M. Amyloid precursor protein and ainyloid-o-peptide bind to and regulate ATP synthase activity at the surface of neural cells. Manuscript in press. Molecular Psychiatry.
Chi SL, Wahl ML, Mowery YM, Shan S, Mukhophadyay S, Hilderbrand SC, Kenan DJ, Lipes BD, Johnson CE, Marusich MF, Capaldi RA, Dewhirst MW, and Pizzo SV. Angiostatin-Re activity of a monoclonal antibody to the catalytic subunit of FIF,, ATP synthase. Cancer Res. 2007 May IS; 67(10)4716-24.
Chi SL, and Pizzo SV. Cell surface FIF,, ATP synthase: A new paradigm? Ann Med. 2006; 38(6):429-38.
Chi SL, and Pizzo SV. Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. Cancer Res 2006 Jan 15; 66(2):875-82.

Fecci PE, Ochiai H, Grossi PM, Sweeney AE, Archer GE, Chewning TA, Mitchell DA, Dranoff G, Allison JP, Bigner DD, and Sampson JH. Systemic blockade of CTLA-4 ameliorates glioma-induced changes to the CD4 T-cell compartment without affecting regulatory T-cell function. Clin Cancer Res 2007; 13(7): 2158-67.
Learn CL, Fecci PE Schmittling RJ, , Xie W, Karikari I, Mitchell DA, Archer GE, Wei Z, Dressman H, Sampson JH. Expression profiling of CD4+, CD8+ and CD4+CD25+CD45RO+FoxP3+ T cells in patients with malignant glioma reveals immunosuppression of the transcriptome. Clin Cancer Res: 2006; 12(24): 7306-15.
Fecci PE, Sweeney AE, Grossi PM, Nair S, Learn CA, Mitchell DA, Cui X, Cummings TM, Bigner DD, and Sampson JH. Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T-cells. Clin Cancer Res 2006; 12(14):4294-305.
Fecci PE, Mitchell DA, Whitesides JF, Xie W, Friedman AH, Archer GE, Herndon JE II, Bigner DD, Dranoff G, and Sampson JH. Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. Cancer Res. 2006; 66(6) 3294-302.
Moon PF, Ramsay MM, Fecci PE, Nathanielsz PW. Fetal exposure to magnesium chloride-adenosine triphosphate (MgCl2-ATP) results in alterations in cerebral blood flow and a metabolic acidosis. Pediatr Crit Care Med 2001; 2(1):74-81.
Fecci PE, Sweeney AE, Mitchell DA, Bigner DD, and Sampson JH. Anti-GITR counters regulatory T-cell function and eliminates well-established malignant glioma. Manuscript in preparation.
Unger JM, Fecci PE, Sweeney AE, Mitchell DA, Sampson JH. Synergism of radiotherapy and regulatory T-cell depletion in the treatment of malignant glioma. Manuscript in preparation.
Mitchell DA, Fecci PE, Sampson JH. Adoptive immunotherapy for malignant glioma. Cancer J 2003; 9(3):157-66.
Fecci PE, Mitchell DA, Archer GE, Morse MA, Lyerly HK, Bigner DD, Sampson JH. The history, evolution, and clinical use of dendritic cell-based immunization strategies for the therapy of brain tumors. J Neurooncol 2003; 64(1-2):161-76.
Fecci PE, Sampson JH. Clinical immunotherapy for brain tumors. Neuroimaging Clin N Am 2002; 12(4):641-64.
Fecci PE, Gromeier M, Sampson JH. Viruses in the treatment of brain tumors. Neuroimaging Clin N Am 2002; 12(4):553-70.
Selznick LA, Fecci PE, Sampson JH. Molecular strategies for the treatment of malignant glioma. Manuscript in preparation.
Mitchell DA, Fecci PE, Sampson JH. “Adoptive immunotherapy for treatment of glioblastoma” in Glioblastoma Multiforme., Markert, J., DeVita, V.T., Rosenberg, S.A., Editors. 2005, Jones and Bartlett Publishers: Sudbury, Mass. Chapter 13.
Fecci PE. The role of regulatory T-cells as barriers to cellular and anti-tumor immunity in patients with malignant brain tumors. Duke University Medical Center Library 2006.

Nucleic Acids Research, High potency silencing by single-stranded boranophosphate siRNA., Hall, A. H. S., Wan, J., Spesock, A., Segueeva, Z., Ramsay Shaw, B., Alexander, K. A., 5/2006 , Volume: 34, Pages: 2773-81.
Ph.D. Dissertation, Duke University, Department of Molecular Genetics and Microbiology, RNA interference as a potential therapy: examining silencing of HPV oncogenes & the behavior of modified siRNAs., Hall, A. H. S., 6/2005.
Nucleic Acids Research, RNA interference using boranophosphate siRNAs: structure-activity relationships., Hall, A. H. S., Wan, J., Shaughnessy, E. E., Ramsay Shaw, B., Alexander, K. A., 11/2004, Volume: 32, Pages: 5991-6000.

Matthew E. Hardee, John P. Kirkpatrick, Siqing Shan, Stacey A. Snyder, Zeljko Vujaskovic, Zahid N. Rabbani, Mark W. Dewhirst, and Kimberly L. Blackwell. Human recombinant erythropoietin (rEpo) has no effect on tumor growth or angiogenesis. British Journal of Cancer 2005. 93 (12): 1350-1355.
Matthew E. Hardee, Murat O. Arcasoy, John P. Kirkpatrick, Kimberly L. Blackwell, Mark W. Dewhirst. Erythropoietin Biology in Cancer. Clinical Cancer Research 2006. 12(2): 332-39.
John P. Kirkpatrick, Matthew E. Hardee, Stacey A. Snyder, Catherine M. Peltz, Yulin Zhao, David M. Brizel, Mark W. Dewhirst, and Kimberly L. Blackwell. The Effect of Darbepoetin Alfa on Growth, Oxygenation and Radioresponsiveness of a Breast Adenocarcinoma. Radiation Research 2006. 165: 192-201.
Matthew E. Hardee, Zahid N. Rabbani, Murat O. Arcasoy, John P. Kirkpatrick, Zeljko Vujaskovic, Mark W. Dewhirst, Kimberly L. Blackwell. Erythropoietin inhibits apoptosis in breast cancer cells in vivo via an Akt-dependent pathway. Molecular Cancer Therapeutics 2006. 5(2): 356-61.
Matthew E. Hardee, Yiting Cao, Xiaohong Jiang, Yulin Zhao, Zahid N. Rabbani, Zeljko Vujaskovic, Mark W. Dewhirst, Murat O. Arcasoy. “Erythropoietin Blockade Inhibits the Induction of Tumor Angiogenesis and Progression” PLoS ONE (In Press).
John P. Kirkpatrick, Jing Mi, Stacey A. Snyder, Zahid N. Rabbani, Shiva Sarraf-Yazdi, Matthew E. Hardee, Brian S. Sorg, Zeljko Vujaskovic, Bryan M. Clary, Kimberly L. Blackwell, and Mark W. Dewhirst. Assessing the Growth, Oxygenation and Radioresponsiveness of a Murine Colon Adenocarcinoma using in vivo Bioluminescent Imaging. Radiation Research (In Review)
J. P. Kirkpatrick, Z. N. Rabbani, R. Bentley, M. E. Hardee, S. Karol, J. A. Meyer, E. Oosterwijk, L. A. Havrilesky, A. A. Secord, Z. Vujaskovic, M. W. Dewhirst, and E. L. Jones. “Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer.” JCO (In Review)
Matthew E. Hardee, Rose J. Eapen, Matthew R. Dreher, , Zahid N. Rabbani, Jeffery Marks, Kimberly L. Blackwell, Mark W. Dewhirst. “Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors” JNCI (In Review).

Kawamoto K, Lobach DF. Proposal for fulfilling strategic objectives of the U.S. roadmap for national action on decision support through a service-oriented architecture leveraging HL7 services. Journal of the American Medical Informatics Association. 2007;14:146-155.
Kawamoto K, Allen LaPointe NM, Silvey GM, Anstrom KJ, Eisenstein EL, Lobach DF. Development and evaluation of an improved methodology for assessing adherence to evidence-based drug therapy guidelines using claims data. Proceedings / AMIA Annual Symposium. 2007;394-8.

Kelly, B.B.*, Wang, D.*, Albrecht, D.E., Adams, M.E., Froehner, S.C., and Feng, G. (in press). Complete deletion of all a.-dystrobrevin isoforms does not reveal new neuromuscular junction phenotype. Gene Expression. *Co-first authors
Kelly, B.S., Hedlund, E., Kim, C., lshiguro, H., lsacson, O., Chikaraishi, D.M., Kim, K.S., & Feng, G. (2006). A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. Neuroscience, 142(2):343-54.

McCoy AN. Platt ML. (2005) Risk-sensitive neurons in macaque posterior cingulate cortex.Nature Neuroscience. 8(9):1220-7, 2005 Sep.
McCoy AN. Platt ML. (2005) Expectations and outcomes: decision-making in the primate brain. Journal of Comparative Physiology A-Sensory Neural & Behavioral Physiology. 191(3):201-11, 2005 Mar.
McCoy AN. Crowley JC. Haghighian G. Dean HL. Platt ML. (2003) Saccade reward signals in posterior cingulate cortex. Neuron. 40(5):1031-40, 2003 Dec 4.

Onyewu, C., E. Eads, W. A. Schell, J. R. Perfect, Y. Ullmann, G. Kaufman, B. A. Horwitz, I. Berdicevsky, and J. Heitman. Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitiors Against Trichophyton Species in vitro and in a Human Skin infection Model. Anti-infective Agents in Medicinal Chemistry, manuscript in review.
Onyewu, C. and J. Heitman. 2007. Unique applications of novel antifungal drug combinations. Anti-infective Agents in Medicinal Chemistry 6:3-15.
Onyewu, C., N. A. Afshari, and J. Heitman. 2006. Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrobial Agents & Chemotherapy 50:3963-3965.
Onyewu C., F. L. Wormley Jr, J.R. Perfect, and J. Heitman. 2004.The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infection and Immunity 72:7330-7333.
Steinbach, W. J., W. A. Schell, J. R. Blankenship, C. Onyewu, J. Heitman, and J. R. Perfect. 2004. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy 48:1664-1669.
Onyewu, C., J. R. Blankenship, M. Del Poeta, and J. Heitman. 2003. Ergosterol Biosynthesis Inhibitors become fungicidal when combined with calcineurin inhibitors in Candida albicans, Candida glabrata, and Candida krusei. Antimicrobial Agents and Chemotherapy 47:956-964.

Palmeri ML, Dahl JJ ,Frinkley KD, Nightingale KR. Quantifying Hepatic Shear Modulus InVivo Using Acoustic Radiation Force. UMB, in submission.
Zhai L, Palmeri ML, Bouchard R, Nightingale RW, Nightingale KR. An integrated Indenter-ARFI imaging system for tissue stiffness quantication. in preparation.
Fahey BJ, Palmeri ML, Trahey GE. The Impact of Physiological Motion on Radiation Force Elasticity Imaging Methods. UMB, in press.
Fahey BJ, Palmeri ML, TraheyGE. Frame Rate Considerations for Real-Time Abdominal Acoustic Radiation Force Impulse Imaging. Ultrasonic Imaging, 28:193-210, 2006.
Dahl JJ, Pinton GF, Palmeri ML, AgrawalV, NightingaleKR, TraheyGE. A Parallel Tracking Method for Acoustic Radiation Force Impulse Imaging. IEEEUFFC, 54(2):301-312, 2006.
Palmeri ML, Trahey GE, Nightingale KR. On the Balance of Energy in Soft Tissue During Diagnostic and Therapeutic Ultrasound. in preparation.
Palmeri ML, McAleavey SA, Trahey GE, Nightingale KR. Ultrasonic Tracking of Acoustic Radiation Force-Induced Displacements in Homogeneous Media. IEEEUFFC, 53(7):1300-1313, 2006.
Palmeri ML, McAleavey SA, Fong KL, Trahey GE, Nightingale KR. Dynamic Mechanical Response of Elastic Spherical Inclusions to Excitation by Impulsive Acoustic Radiation Force. IEEEUFFC, 53(11):2065-2079, 2006.
Palmeri ML, Frinkley KD, Oldenburg KG, Trahey GE, Nightingale KR. Characterizing Acoustic Attenuation of Homogeneous Media Using Focused Impulsive Acoustic Radiation Force. Ultrasonic Imaging, 28: 114-128, 2006.
Palmeri ML,Oldenburg KG,Nightingale KR. Ultrasonic Tracking of Structures with Low SNR. In preparation.
Palmeri ML, Frinkley KD, Zhai L, Bentley RC, Ludwig K, Gottfried M, Nightingale KR. Acoustic Radiation Force Impulse Imaging of the Gastrointestinal Tract. UltrasonicImaging, 27:75-88, 2005.
Palmeri ML, Sharma AC, Bouchard RR, Nightingale RW, Nightingale KR. AFinite-Element Method Model of Soft Tissue Response to Impulsive Acoustic Radiation Force. IEEEUFFC, 52(10):1699-1712, 2005.
Palmeri ML, Frinkley KD, Nightingale KR. Experimental Studies of the Thermal Effects Associated with Radiation Force Imaging of Soft Tissue Ultrasonic Imaging, 26:100-114, 2004.
Palmeri ML, Nightingale KR. On the thermal effects associated with acoustic radiation force impulse imaging. IEEEUFFC, 51(5):551-565, 2004.
Fahey BJ, Nightingale KR, Nelson RC, Palmeri ML, Trahey GE. Acoustic Radiation Force Impulse Imaging of the Abdomen: Demonstration of Feasibility and Utility UMB, 31(9):1185-1198, 2005.
Fahey BJ, Nightingale KR, Palmeri ML, McAleavey SA, Wolf P, Trahey GE. Acoustic radiation forceimpulse imaging of myocardial radiofrequency ablation: initial in vivo results. IEEEUFFC, 52(4):631-641, 2005.
Trahey GE, Palmeri ML, Bentley RC, Nightingale KR. Acoustic Radiation Force Impulse Imaging of the Mechanical Properties of Arteries: In vivo and Ex vivo Results. UMB, 30(9):1163-1171, 2004.
Gentry KL, Palmeri ML, Sachedina N, Smith SW. Finite Element Analysis of Temperature Rise and Lesion Formation from Catheter Ultrasound Ablation Transducers. IEEEUFFC, 52(10):1713-1721, 2005.
Nightingale KR, Palmeri ML, Trahey GE. Analysis of Factors Affecting Image Quality in Radiation Force Generated Images. UMB, 32(1):61-72, 2006.
Nightingale KR, Palmeri ML, Nightingale RW, Trahey GE. On the feasibility of remote palpation using acoustic radiation force. JASA, 110(1):625-634, 2001.
Nightingale KR, Nightingale RW, Palmeri ML,Trahey GE. A finite element model of remote palpation of breast lesions using ultrasonic acoustic radiation force: factors affecting tissue displacement. Ultrasonic Imaging, 22(1):35-54, 2000.

Ream M, Ray AM, Chandra R, Peavey M, Chikaraishi DM. Hypoxia leads to myocardial thinning and death in the midgestation fetus. In preparation.
Ream M, Ray AM, Peavey M, Kim H, Wetsel W, Rockman H, Roffler-Tarlov S, Chikaraishi DM. Hyperoxia rescues fetal lethality associated with norepinephrine deficiency. In preparation.
Ream M, Frush D. Dancing eyes and dancing feet, a clinical review of neuroblastoma and associated opsoclonus-myoclonus syndrome for radiologists. In preparation.
Chandra R, Portbury AL, Ray A, Ream M, Groelle M, Chikaraishi DM. Beta1-adrenergic receptors maintain fetal heart rate and survival. Biology of the Neonate, 89: 147-158, 2006.

James L. Pearson, Timothy J. Robinson, Caroline Le Sommer, Manuel J. Muñoz, Alberto R. Kornblihtt, and Mariano A. Garcia-Blanco. Identification of the Cellular Targets of the Transcription Factor CA150 (TCERG1) Reveals a Widespread Role in mRNA Processing. (in review)